Southampton U21
| England - EFL Trophy | 09/14 18:00 | - |
[2] Leyton Orient
v
Southampton U21
[2] 
|
L | 1-0 | |
| England - EFL Trophy | 11/11 19:00 | - |
[1] Milton Keynes Dons
v
Southampton U21
[4]
|
W | 1-2 | |
| England - EFL Trophy | 10/06 18:30 | - |
[4] Northampton
v
Southampton U21
[3]
|
L | 5-0 | |
| England - EFL Trophy | 09/22 18:00 | - |
[2] Stevenage
v
Southampton U21
[2]
|
L | 2-1 | |
| England - EFL Trophy | 11/05 19:45 | 1 |
[3] Coventry
v
Southampton U21
[4]
|
L | 3-2 | |
| England - EFL Trophy | 10/01 18:00 | 1 |
[3] Walsall
v
Southampton U21
[4]
|
L | 1-0 | |
| England - EFL Trophy | 09/03 18:00 | 1 |
Forest Green
v
Southampton U21
|
L | 3-2 | |
| England - Premier League 2 | 11/23 19:00 | 1 |
Norwich U21
v
Southampton U21
|
D | 0-0 | |
| England - EFL Trophy | 11/14 19:45 | 3 |
[2] Southend
v
Southampton U21
[4]
|
L | 3-0 | |
| England - EFL Trophy | 10/09 18:00 | 2 |
[3] Cambridge Utd
v
Southampton U21
[2]
|
L | 4-0 | |
| England - EFL Trophy | 09/04 18:45 | 1 |
Colchester
v
Southampton U21
|
W | 0-2 | |
| England - EFL Trophy | 11/07 19:45 | 3 |
[1] Northampton
v
Southampton U21
[3]
|
L | 7-5 | |
| England - EFL Trophy | 10/03 18:00 | 2 |
[3] Cambridge Utd
v
Southampton U21
[4]
|
W | 0-1 | |
| England - EFL Trophy | 08/29 18:45 | 1 |
Peterborough
v
Southampton U21
|
L | 2-0 | |
| England - Premier League 2 | 08/14 18:00 | 1 |
Southampton U21
v
Reading U21
|
W | 4-0 | |
| England - Premier League 2 | 09/19 18:00 | 1 |
Southampton U21
v
Leicester U21
|
D | 2-2 | |
| England - EFL Trophy | 08/30 18:45 | 1 |
Charlton
v
Southampton U21
|
L | 5-4 | |
| England - Premier League 2 | 08/22 18:00 | 1 |
Southampton U21
v
Man Utd U21
|
W | 2-0 | |
| England - Premier League 2 | 08/14 12:00 | 1 |
Liverpool U21
v
Southampton U21
|
W | 1-4 |
Southampton U21 er reserve- og ungdomslaget til Southampton FC. Laget spiller i Premier League 2, som er det øverste nivået for ungdomsfotball i England.
Laget har vunnet Premier League 2 to ganger, i sesongene 2010–11 og 2014–15. Southampton U21 har også vunnet FA Youth Cup én gang, i sesongen 2016–17.
Laget har vunnet Premier League 2 to ganger, i sesongene 2010–11 og 2014–15. Southampton U21 har også vunnet FA Youth Cup én gang, i sesongen 2016–17.