Southampton U21
| England - Premier League 2 | 04/29 11:00 | 13 |
[16] Southampton U21
v
Man Utd U21
[15] 
|
L | 3-6 | |
| England - Premier League 2 | 04/26 18:00 | 20 |
[5] Chelsea U21
v
Southampton U21
[16]
|
L | 2-0 | |
| England - Premier League 2 | 04/12 18:00 | 19 |
[14] Southampton U21
v
Nottm Forest U21
[17] 
|
D | 1-1 | |
| England - Premier League 2 | 04/05 18:00 | 18 |
[15] Norwich U21
v
Southampton U21
[16]
|
W | 0-2 | |
| England - Premier League 2 | 03/15 19:00 | 17 |
[18] Southampton U21
v
Crystal Palace U21
[11] 
|
W | 4-0 | |
| England - Premier League 2 | 03/08 19:00 | 16 |
[20] Southampton U21
v
Stoke U21
[14] 
|
W | 5-1 | |
| England - Premier League 2 | 03/04 18:00 | 15 |
[19] West Brom U21
v
Southampton U21
[21]
|
D | 1-1 | |
| England - Premier League 2 | 02/16 19:00 | 14 |
[3] Arsenal U21
v
Southampton U21
[18]
|
L | 4-2 | |
| England - Premier League 2 | 02/09 19:00 | 13 |
Southampton U21
v
Man Utd U21
|
- | Postponed | |
| England - Premier League 2 | 01/29 19:00 | 12 |
[22] Leicester U21
v
Southampton U21
[19]
|
W | 1-2 | |
| Premier League - International Cup | 01/24 19:00 | 1 |
[6] Southampton U21
v
Celtic U21
[8] 
|
L | 1-3 | |
| England - Premier League 2 | 01/12 19:00 | 11 |
[17] Southampton U21
v
Tottenham U21
[1] 
|
L | 2-3 | |
| Premier League - International Cup | 12/20 19:00 | 1 |
[6] Southampton U21
v
Dinamo Zagreb U21
[7] |
D | 2-2 | |
| England - Premier League 2 | 12/15 11:30 | 10 |
[21] Southampton U21
v
Derby U21
[19] 
|
W | 2-1 | |
| England - Premier League 2 | 12/04 19:00 | 9 |
[24] Everton U21
v
Southampton U21
[18]
|
L | 5-0 | |
| Premier League - International Cup | 11/28 19:00 | 1 |
[5] Southampton U21
v
Valencia U21
[6] 
|
L | 0-2 | |
| England - Premier League 2 | 11/03 12:00 | 8 |
[17] Southampton U21
v
Sunderland U21
[9] 
|
L | 1-2 | |
| England - Premier League 2 | 10/30 19:00 | 7 |
[19] Wolverhampton U21
v
Southampton U21
[16]
|
L | 2-1 | |
| Premier League - International Cup | 10/04 18:00 | 1 |
[3] Southampton U21
v
Lyon U21
[2] |
L | 3-4 | |
| England - Premier League 2 | 09/29 18:00 | 6 |
[19] Southampton U21
v
Reading U21
[4] 
|
W | 6-0 | |
| England - Premier League 2 | 09/22 18:00 | 5 |
[5] West Ham U21
v
Southampton U21
[23]
|
D | 3-3 | |
| England - Premier League 2 | 09/01 14:00 | 4 |
[2] Fulham U21
v
Southampton U21
[18]
|
L | 5-1 | |
| England - Premier League 2 | 08/25 17:00 | 3 |
[9] Southampton U21
v
Liverpool U21
[6] 
|
L | 0-3 | |
| England - Premier League 2 | 08/18 18:00 | 2 |
[18] Southampton U21
v
Aston Villa U21
[22] 
|
W | 4-2 | |
| England - Premier League 2 | 08/13 11:30 | 1 |
[14] Newcastle U21
v
Southampton U21
[18]
|
L | 5-3 | |
| England - Premier League 2 | 04/23 13:00 | 22 |
[6] Norwich U21
v
Southampton U21
[3]
|
W | 2-5 | |
| England - Premier League 2 | 04/14 18:00 | 21 |
[2] Southampton U21
v
Stoke U21
[10]
|
W | 2-0 | |
| England - Premier League 2 | 03/31 18:00 | 5 |
[11] Derby U21
v
Southampton U21
[3]
|
W | 1-3 | |
| England - Premier League 2 | 03/17 18:00 | 19 |
[4] Aston Villa U21
v
Southampton U21
[3]
|
W | 1-2 | |
| England - Premier League Cup - U21 | 03/10 19:00 | 3 |
Southampton U21
v
Blackburn U21
|
L | 1-4 |
Southampton U21 er reserve- og ungdomslaget til Southampton FC. Laget spiller i Premier League 2, som er det øverste nivået for ungdomsfotball i England.
Laget har vunnet Premier League 2 to ganger, i sesongene 2010–11 og 2014–15. Southampton U21 har også vunnet FA Youth Cup én gang, i sesongen 2016–17.
Laget har vunnet Premier League 2 to ganger, i sesongene 2010–11 og 2014–15. Southampton U21 har også vunnet FA Youth Cup én gang, i sesongen 2016–17.