| NCAAF | 09/25 17:00 | 1 | Mercyhurst Lakers v Iup Crimson Hawks | L | 13-48 | |
| NCAAF | 09/18 17:05 | 1 | East Stroudsburg Warriors v Mercyhurst Lakers | L | 17-7 | |
| NCAAF | 09/11 16:00 | 1 | Mercyhurst Lakers v West Chester Golden Rams | L | 10-56 | |
| NCAAF | 09/04 22:00 | 1 |
Mercyhurst Lakers
v
Alderson Broaddus Battlers
|
W | 18-3 | |
| NCAAF | 11/16 17:00 | 1 | Millersville University of Pennsylvania Marauders v Mercyhurst Lakers | W | 7-17 | |
| NCAAF | 11/09 17:00 | 1 | Clarion Golden Eagles v Mercyhurst Lakers | W | 10-57 | |
| NCAAF | 11/02 16:00 | 1 | Mercyhurst Lakers v Gannon University Golden Knights | W | 28-7 | |
| NCAAF | 10/26 17:00 | 1 | California Vulcans v Mercyhurst Lakers | L | 27-15 | |
| NCAAF | 10/19 16:00 | 1 | Mercyhurst Lakers v Seton Hill Griffins | L | 20-30 | |
| NCAAF | 10/12 18:00 | 1 | Edinboro Fighting Scots v Mercyhurst Lakers | W | 23-44 | |
| NCAAF | 10/05 16:00 | 1 | Mercyhurst Lakers v Slippery Rock | L | 14-45 | |
| NCAAF | 09/28 17:00 | 1 | Mercyhurst Lakers v Iup Crimson Hawks | L | 24-56 | |
| NCAAF | 09/21 18:00 | 1 | Bloomsburg Huskies v Mercyhurst Lakers | W | 24-38 | |
| NCAAF | 09/14 19:00 | 1 | Mercyhurst Lakers v Shepherd Rams | L | 17-22 | |
| NCAAF | 09/05 23:00 | 1 | Mercyhurst Lakers v Lake Erie | W | 21-16 | |
| NCAAF | 11/10 17:00 | 1 | Mercyhurst Lakers v Millersville University of Pennsylvania Marauders | W | 35-14 | |
| NCAAF | 11/03 16:00 | 1 | Mercyhurst Lakers v Clarion Golden Eagles | W | 14-7 | |
| NCAAF | 10/27 16:00 | 1 | Gannon University Golden Knights v Mercyhurst Lakers | W | 21-38 | |
| NCAAF | 10/20 16:00 | 1 | Mercyhurst Lakers v California Vulcans | L | 0-23 | |
| NCAAF | 10/13 16:00 | 1 | Seton Hill Griffins v Mercyhurst Lakers | L | 34-33 | |
| NCAAF | 10/06 16:00 | 1 | Mercyhurst Lakers v Edinboro Fighting Scots | W | 24-6 | |
| NCAAF | 09/29 22:00 | 1 | Slippery Rock v Mercyhurst Lakers | L | 41-21 | |
| NCAAF | 09/22 20:00 | 1 | Iup Crimson Hawks v Mercyhurst Lakers | L | 34-7 | |
| NCAAF | 09/15 17:00 | 1 | Mercyhurst Lakers v Bloomsburg Huskies | W | 14-10 | |
| NCAAF | 09/08 16:00 | 1 | Mercyhurst Lakers v Tiffin Dragons | L | 20-24 | |
| NCAAF | 09/01 23:00 | 1 | Hillsdale Chargers v Mercyhurst Lakers | L | 14-9 |