[61] Michigan State 7-49 Iowa [124] 2020-11-07 17:00
Stadium: Kinnick Stadium Round: 1
Head to Head
| NCAAF | 2017/09/30 20:00 | Iowa v Michigan State | W | 10-17 |
| NCAAF | 2015/12/06 01:17 | Iowa v Michigan State | W | 13-16 |
| NCAAF | 2012/10/13 12:00 | Michigan State v Iowa | L | 16-19 |
| NCAAF | 2011/11/12 12:00 | Iowa v Michigan State | W | 21-37 |
| NCAAF | 2010/10/30 12:00 | Iowa v Michigan State | L | 37-6 |
| NCAAF | 2009/10/24 12:00 | Michigan State v Iowa | L | 13-15 |
| NCAAF | 2008/10/04 12:00 | Michigan State v Iowa | W | 16-13 |
| NCAAF | 2007/10/27 12:00 | Iowa v Michigan State | L | 34-27 |
| NCAAF | 2004/10/02 12:00 | Iowa v Michigan State | L | 38-16 |
| NCAAF | 2003/09/27 12:00 | Michigan State v Iowa | W | 20-10 |
| NCAAF | 2002/10/12 12:00 | Iowa v Michigan State | L | 44-16 |
| NCAAF | 2001/10/13 12:00 | Michigan State v Iowa | W | 31-28 |
| NCAAF | 2000/10/07 12:00 | Iowa v Michigan State | L | 21-16 |