Head to Head
| NCAAF | 2015/09/12 16:00 | Louisville v Houston | L | 31-34 |
| NCAAF | 2004/11/20 12:00 | Houston v Louisville | W | 27-65 |
| NCAAF | 2003/11/22 12:00 | Louisville v Houston | W | 66-45 |
| NCAAF | 2002/11/30 12:00 | Houston v Louisville | L | 27-10 |
| NCAAF | 2001/11/10 12:00 | Louisville v Houston | W | 34-10 |
| NCAAF | 2000/11/18 12:00 | Houston v Louisville | W | 13-32 |
Home History
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | W | 12-44 |
| NCAAF | 2016/11/05 16:00 | Louisville v Boston College | W | 52-7 |
| NCAAF | 2016/10/29 16:00 | Louisville v Virginia | W | 32-25 |
| NCAAF | 2016/10/22 16:00 | NC State v Louisville | W | 13-54 |
| NCAAF | 2016/10/14 23:00 | Duke v Louisville | W | 14-24 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | L | 36-42 |
| NCAAF | 2016/09/25 00:00 | Louisville v Marshall | W | 59-28 |
| NCAAF | 2016/09/17 16:00 | Florida State v Louisville | W | 20-63 |
Away History
| NCAAF | 2016/11/12 20:30 | Tulane v Houston | W | 18-30 |
| NCAAF | 2016/10/29 16:00 | Central Florida v Houston | W | 24-31 |
| NCAAF | 2016/10/22 23:00 | Houston v SMU | L | 16-38 |
| NCAAF | 2016/10/15 23:00 | Tulsa v Houston | W | 31-38 |
| NCAAF | 2016/10/08 19:00 | Houston v Navy | L | 40-46 |
| NCAAF | 2016/09/30 00:00 | Connecticut v Houston | W | 14-42 |
| NCAAF | 2016/09/24 23:00 | Houston v Texas State | W | 64-3 |
| NCAAF | 2016/09/15 23:30 | Houston v Cincinnati | W | 40-16 |