Stadium: Panther Stadium Round: 1
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | W | 7-38 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2019/11/09 18:00 | Ohio Dominican Panthers v Lake Erie | W | 49-10 |
| NCAAF | 2018/11/10 17:00 | Lake Erie v Ohio Dominican Panthers | W | 6-62 |
| NCAAF | 2023/09/30 17:00 | Ohio Dominican Panthers v Ashland Eagles | L | 6-20 |
| NCAAF | 2023/09/23 23:00 | Kentucky Wesleyan v Ohio Dominican Panthers | L | 13-10 |
| NCAAF | 2023/09/16 23:00 | Thomas More Saints v Ohio Dominican Panthers | L | 18-17 |
| NCAAF | 2023/09/09 19:30 | Ohio Dominican Panthers v Winston-Salem State | W | 26-14 |
| NCAAF | 2023/09/02 16:00 | Notre Dame Falcons v Ohio Dominican Panthers | L | 23-21 |
| NCAAF | 2022/11/12 18:00 | Ohio Dominican Panthers v Hillsdale Chargers | W | 20-10 |
| NCAAF | 2022/11/05 17:00 | Northwood Timberwolves v Ohio Dominican Panthers | W | 24-35 |
| NCAAF | 2022/10/22 17:00 | Ohio Dominican Panthers v Kentucky Wesleyan | W | 49-7 |
| NCAAF | 2023/09/30 22:00 | Lake Erie v Walsh U. Cavaliers | L | 16-30 |
| NCAAF | 2023/09/23 17:00 | Northwood Timberwolves v Lake Erie | L | 68-14 |
| NCAAF | 2023/09/16 23:00 | Lake Erie v Findlay Oilers | L | 3-45 |
| NCAAF | 2023/09/09 17:00 | Northern Michigan Wildcats v Lake Erie | W | 21-24 |
| NCAAF | 2023/09/02 17:00 | Lake Erie v Franklin Pierce Ravens | L | 10-26 |
| NCAAF | 2022/11/12 17:00 | Lake Erie v Northern Michigan Wildcats | L | 11-33 |
| NCAAF | 2022/11/05 20:00 | Lake Erie v Ashland Eagles | L | 23-31 |
| NCAAF | 2022/10/29 16:00 | Findlay Oilers v Lake Erie | L | 42-17 |