Stadium: John O'Quinn Field at TDECU Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Jeff Traylor
| NCAAF | 2022/09/03 19:30 | Houston v Texas-San Antonio | L | 37-35 |
| NCAAF | 2014/08/30 01:00 | Houston v Texas-San Antonio | W | 7-27 |
| NCAAF - Bowl Games | 2022/12/16 20:00 | Troy v Texas-San Antonio | L | 18-12 |
| NCAAF | 2022/12/03 00:30 | North Texas v Texas-San Antonio | W | 27-48 |
| NCAAF | 2022/11/26 20:30 | UTEP v Texas-San Antonio | W | 31-34 |
| NCAAF | 2022/11/19 18:00 | Texas-San Antonio v Rice | W | 41-7 |
| NCAAF | 2022/11/12 20:30 | Louisiana Tech v Texas-San Antonio | W | 7-51 |
| NCAAF | 2022/11/05 19:30 | Texas-San Antonio v UAB | W | 44-38 |
| NCAAF | 2022/10/22 19:30 | North Texas v Texas-San Antonio | W | 27-31 |
| NCAAF | 2022/10/15 00:00 | Texas-San Antonio v Florida Intl | W | 30-10 |
| NCAAF - Bowl Games | 2022/12/23 20:00 | Houston v Lafayette | W | 23-16 |
| NCAAF | 2022/11/27 00:30 | Tulsa v Houston | L | 37-30 |
| NCAAF | 2022/11/19 19:00 | Houston v East Carolina | W | 42-3 |
| NCAAF | 2022/11/12 20:00 | Temple v Houston | W | 36-43 |
| NCAAF | 2022/11/05 23:00 | Houston v SMU | L | 63-77 |
| NCAAF | 2022/10/29 16:00 | South Florida v Houston | W | 27-42 |
| NCAAF | 2022/10/22 16:00 | Houston v Navy | W | 38-20 |
| NCAAF | 2022/10/08 12:28 | Houston v Tulane | D | 0-0 |