[127] South Florida 27-42 Houston [57] 2022-10-29 16:00
Stadium: John O'Quinn Field at TDECU Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Jeff Scott
Head to Head
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |
| NCAAF | 2020/11/14 20:30 | South Florida v Houston | L | 21-56 |
| NCAAF | 2018/10/27 19:30 | South Florida v Houston | L | 36-57 |
| NCAAF | 2017/10/28 19:45 | Houston v South Florida | L | 28-24 |
| NCAAF | 2014/11/01 20:00 | South Florida v Houston | L | 3-27 |
| NCAAF | 2002/11/23 12:00 | Houston v South Florida | W | 14-32 |
| NCAAF | 2001/11/03 12:00 | South Florida v Houston | W | 45-6 |
Home History
| NCAAF | 2022/10/15 20:00 | Tulane v South Florida | L | 45-31 |
| NCAAF | 2022/10/08 18:30 | South Florida v Cincinnati | L | 24-28 |
| NCAAF | 2022/10/01 18:30 | East Carolina v South Florida | L | 48-28 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | L | 3-41 |
| NCAAF | 2022/09/17 23:30 | South Florida v Florida | L | 28-31 |
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | W | 20-42 |
| NCAAF | 2022/09/03 20:00 | BYU v South Florida | L | 50-21 |
| NCAAF | 2021/11/26 20:30 | South Florida v Central Florida | L | 13-17 |
Away History
| NCAAF | 2022/10/22 16:00 | Houston v Navy | W | 38-20 |
| NCAAF | 2022/10/08 12:28 | Houston v Tulane | D | 0-0 |
| NCAAF | 2022/10/07 23:30 | Houston v Memphis | W | 33-32 |
| NCAAF | 2022/09/30 23:00 | Tulane v Houston | L | 27-24 |
| NCAAF | 2022/09/24 22:00 | Rice v Houston | W | 27-34 |
| NCAAF | 2022/09/17 20:00 | Kansas v Houston | L | 48-30 |
| NCAAF | 2022/09/10 20:00 | Houston v Texas Tech | L | 30-33 |
| NCAAF | 2022/09/03 19:30 | Houston v Texas-San Antonio | W | 37-35 |