[5] Mississippi 52-28 Vanderbilt [11] 2022-10-08 20:00
Stadium: Vanderbilt Stadium Round: 1
Home Manager: Clark Lea Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2021/11/21 00:30 | Vanderbilt v Mississippi | W | 17-31 |
| NCAAF | 2020/10/31 20:00 | Mississippi v Vanderbilt | W | 54-21 |
| NCAAF | 2019/10/05 23:30 | Vanderbilt v Mississippi | W | 6-31 |
| NCAAF | 2018/11/18 00:30 | Mississippi v Vanderbilt | L | 29-36 |
| NCAAF | 2017/10/14 19:30 | Vanderbilt v Mississippi | W | 35-57 |
| NCAAF | 2016/11/20 01:00 | Mississippi v Vanderbilt | L | 17-38 |
| NCAAF | 2015/09/26 23:00 | Mississippi v Vanderbilt | W | 27-16 |
| NCAAF | 2014/09/06 20:30 | Vanderbilt v Mississippi | W | 3-41 |
Home History
| NCAAF | 2022/10/01 16:00 | Kentucky v Mississippi | W | 19-22 |
| NCAAF | 2022/09/24 20:00 | Tulsa v Mississippi | W | 27-35 |
| NCAAF | 2022/09/17 19:30 | Mississippi v Georgia Tech | W | 42-0 |
| NCAAF | 2022/09/10 23:00 | Central Arkansas v Mississippi | W | 3-59 |
| NCAAF | 2022/09/03 20:00 | Troy v Mississippi | W | 10-28 |
| NCAAF - Bowl Games | 2022/01/02 01:45 | Baylor v Mississippi | L | 21-7 |
| NCAAF | 2021/11/26 00:30 | Mississippi v Mississippi State | W | 31-21 |
| NCAAF | 2021/11/21 00:30 | Vanderbilt v Mississippi | W | 17-31 |
Away History
| NCAAF | 2022/09/24 23:30 | Vanderbilt v Alabama | L | 3-55 |
| NCAAF | 2022/09/17 19:30 | Vanderbilt v Northern Illinois | W | 38-28 |
| NCAAF | 2022/09/10 16:00 | Wake Forest v Vanderbilt | L | 45-25 |
| NCAAF | 2022/09/03 23:00 | Elon v Vanderbilt | W | 31-42 |
| NCAAF | 2022/08/28 02:30 | Vanderbilt v Hawaii | W | 63-10 |
| NCAAF | 2021/11/27 20:45 | Vanderbilt v Tennessee | L | 21-45 |
| NCAAF | 2021/11/21 00:30 | Vanderbilt v Mississippi | L | 17-31 |
| NCAAF | 2021/11/14 00:00 | Kentucky v Vanderbilt | L | 34-17 |