Stadium: Provost Umphrey Stadium Round: 1
Home Manager: Blane Morgan Away Manager: Bubba McDowell
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | L | 45-13 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | W | 34-14 |
| NCAAF | 2022/09/24 22:00 | Prairie View v Alabama State | W | 25-15 |
| NCAAF | 2022/09/17 23:00 | Incarnate Word v Prairie View | L | 31-14 |
| NCAAF | 2022/09/11 00:00 | Prairie View v Abilene Christian | L | 13-21 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | W | 23-40 |
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | L | 10-27 |
| NCAAF | 2021/11/27 20:00 | Mississippi Valley State v Prairie View | L | 24-19 |
| NCAAF | 2022/10/08 21:00 | Lamar v Incarnate Word | L | 17-56 |
| NCAAF | 2022/10/01 20:00 | Houston Christian v Lamar | L | 37-34 |
| NCAAF | 2022/09/24 20:30 | Lamar v Northwestern State | L | 27-35 |
| NCAAF | 2022/09/17 23:00 | Northern Colorado v Lamar | L | 21-14 |
| NCAAF | 2022/09/10 23:00 | Lamar v SMU | L | 16-45 |
| NCAAF | 2022/09/02 00:00 | Lamar v Abilene Christian | L | 14-28 |
| NCAAF | 2021/11/20 22:00 | Stephen F. Austin v Lamar | L | 42-6 |
| NCAAF | 2021/11/13 22:00 | Jacksonville State v Lamar | L | 38-7 |