Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Walt Wells
| NCAAF | 2019/11/09 19:00 | Eastern Kentucky v SE Missouri St | L | 31-38 |
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | W | 14-23 |
| NCAAF | 2017/09/30 23:00 | SE Missouri St v Eastern Kentucky | L | 29-10 |
| NCAAF | 2022/10/22 19:00 | North Alabama v Eastern Kentucky | W | 53-56 |
| NCAAF | 2022/10/15 22:00 | Sam Houston State v Eastern Kentucky | L | 25-17 |
| NCAAF | 2022/10/01 22:00 | Southern Utah v Eastern Kentucky | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Eastern Kentucky v Austin Peay | L | 20-31 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | W | 17-40 |
| NCAAF | 2022/09/10 20:00 | Eastern Kentucky v Bowling Green | W | 59-57 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | L | 34-42 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2022/10/22 18:00 | SE Missouri St v Northwestern State | W | 51-16 |
| NCAAF | 2022/10/08 19:00 | Tennessee Tech v SE Missouri St | W | 20-34 |
| NCAAF | 2022/10/01 18:00 | SE Missouri St v Lindenwood | W | 49-28 |
| NCAAF | 2022/09/24 19:00 | Central Arkansas v SE Missouri St | W | 27-35 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | W | 16-42 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | W | 34-31 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |