Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Bob Nielson
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | L | 20-14 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | W | 27-20 |
| NCAAF | 2017/10/21 19:00 | Illinois State v South Dakota | L | 37-21 |
| NCAAF | 2022/10/08 19:00 | South Dakota v South Dakota State | L | 3-28 |
| NCAAF | 2022/09/24 18:00 | North Dakota State v South Dakota | L | 34-17 |
| NCAAF | 2022/09/17 18:00 | Cal Poly v South Dakota | W | 21-38 |
| NCAAF | 2022/09/10 19:30 | South Dakota v Montana | L | 7-24 |
| NCAAF | 2022/09/03 23:00 | South Dakota v Kansas State | L | 0-34 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | L | 22-10 |
| NCAAF | 2021/11/20 20:30 | South Dakota v North Dakota State | L | 24-52 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | W | 20-23 |
| NCAAF | 2022/10/08 21:00 | Illinois State v Northern Iowa | W | 23-21 |
| NCAAF | 2022/10/01 23:30 | SO Illinois v Illinois State | L | 19-14 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | W | 7-35 |
| NCAAF | 2022/09/10 23:30 | Valparaiso v Illinois State | W | 21-28 |
| NCAAF | 2022/09/03 23:00 | Illinois State v Wisconsin | L | 0-38 |
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | L | 15-10 |
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | L | 7-14 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |