Stadium: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: Autry Denson
| NCAAF | 2022/09/10 16:30 | Charleston Southern v NC State | L | 3-55 |
| NCAAF | 2022/09/03 16:00 | Western Carolina v Charleston Southern | L | 52-38 |
| NCAAF | 2021/11/20 17:00 | Charleston Southern v Georgia | L | 7-56 |
| NCAAF | 2021/11/13 18:30 | Charleston Southern v Gardner Webb | W | 32-24 |
| NCAAF | 2021/11/06 17:00 | North Carolina A&T v Charleston Southern | L | 21-18 |
| NCAAF | 2021/10/30 17:00 | Campbell v Charleston Southern | W | 14-27 |
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama | L | 22-45 |
| NCAAF | 2021/10/16 22:00 | Hampton v Charleston Southern | W | 5-35 |
| NCAAF | 2022/09/10 20:00 | Eastern Kentucky v Bowling Green | W | 59-57 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | L | 34-42 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2021/11/13 18:00 | Eastern Kentucky v Sam Houston State | L | 28-42 |
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | L | 17-31 |
| NCAAF | 2021/10/30 18:00 | Lamar v Eastern Kentucky | W | 10-42 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | W | 38-35 |
| NCAAF | 2021/10/09 22:00 | Abilene Christian v Eastern Kentucky | W | 15-30 |