Stadium: Ernest W. Spangler Stadium Round: 1
Home Manager: Tre Lamb Away Manager: Drew Cronic
| NCAAF | 2022/09/17 22:00 | The Citadel v Mercer | W | 0-17 |
| NCAAF | 2022/09/03 23:00 | Mercer v Auburn | L | 16-42 |
| NCAAF | 2022/08/27 23:00 | Morehead State v Mercer | W | 13-63 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | L | 35-38 |
| NCAAF | 2021/11/13 20:00 | Tennessee Chattanooga v Mercer | W | 6-10 |
| NCAAF | 2021/10/30 18:00 | Mercer v The Citadel | W | 34-7 |
| NCAAF | 2021/10/23 22:00 | Wofford v Mercer | W | 14-45 |
| NCAAF | 2021/10/16 20:00 | VMI v Mercer | L | 45-7 |
| NCAAF | 2022/09/17 22:00 | Gardner Webb v Elon | L | 24-30 |
| NCAAF | 2022/09/10 22:00 | Gardner Webb v Coastal Carolina | L | 27-31 |
| NCAAF | 2022/09/01 23:00 | Gardner Webb v Limestone Saints | W | 56-21 |
| NCAAF | 2021/11/20 18:00 | Gardner Webb v North Carolina A&T | W | 35-27 |
| NCAAF | 2021/11/13 18:30 | Charleston Southern v Gardner Webb | L | 32-24 |
| NCAAF | 2021/11/06 17:00 | Gardner Webb v Hampton | L | 21-27 |
| NCAAF | 2021/10/30 17:00 | Gardner Webb v Kennesaw State | L | 30-34 |
| NCAAF | 2021/10/23 17:30 | Robert Morris v Gardner Webb | W | 17-28 |