[11] Cameron Norrie 6-4,6-7,6-4 John Isner [23] 2022-05-04 12:25
Stadium: Court 4 Round: 25 Ground: Clay
Head to Head
| ATP Acapulco | 2022/02/24 00:00 | Cameron Norrie v John Isner | 6-7,6-3,6-4 |
| ATP Cincinnati | 2021/08/17 17:55 | John Isner v Cameron Norrie | 4-6,7-6,6-4 |
| ATP Wien | 2018/10/23 13:30 | Cameron Norrie v John Isner | 7-6,4-6,6-7 |
| ATP Lyon | 2018/05/24 09:00 | Cameron Norrie v John Isner | 7-6,6-4 |
Home History
| ATP Madrid | 2022/05/02 15:40 | Cameron Norrie v Soonwoo Kwon | 7-5,7-5 |
| ATP Barcelona | 2022/04/22 17:30 | Cameron Norrie v Alex De Minaur | 3-6,7-5,1-6 |
| ATP Barcelona | 2022/04/22 11:30 | Cameron Norrie v Marton Fucsovics | 7-5,6-7,6-4 |
| ATP Barcelona | 2022/04/19 15:20 | Cameron Norrie v Egor Gerasimov | 5-7,6-4,6-4 |
| ATP Monte Carlo | 2022/04/13 09:00 | Albert Ramos-Vinolas v Cameron Norrie | 6-4,2-6,6-4 |
| ATP Miami | 2022/03/29 15:00 | Casper Ruud v Cameron Norrie | 6-3,6-4 |
| ATP Miami | 2022/03/27 15:00 | Hugo Gaston v Cameron Norrie | 3-6,5-7 |
| ATP Miami | 2022/03/25 15:00 | Jack Draper v Cameron Norrie | 6-7,4-6 |
Away History
| ATP Madrid | 2022/05/01 13:00 | Filip Krajinovic v John Isner | 6-7,4-6 |
| ATP Houston | 2022/04/10 19:00 | Reilly Opelka v John Isner | 6-3,7-6 |
| ATP Houston | 2022/04/09 19:30 | John Isner v Cristian Garin | 4-6,6-3,6-4 |
| ATP Houston | 2022/04/08 23:00 | Frances Tiafoe v John Isner | 4-6,6-2,3-6 |
| ATP Houston | 2022/04/08 01:55 | Steve Johnson v John Isner | 7-6,6-7,3-6 |
| ATP Miami | 2022/03/25 18:05 | John Isner v Hugo Gaston | 6-7,4-6 |
| ATP Indian Wells | 2022/03/16 21:30 | John Isner v Grigor Dimitrov | 3-6,6-7 |
| ATP Indian Wells | 2022/03/15 22:05 | Diego Schwartzman v John Isner | 5-7,3-6 |