Stadium: Leavey Center
Home Manager: Herb Sendek Away Manager: Sam Scholl
| NCAAB | 2021/02/19 02:00 | San Diego v Santa Clara | W | 71-60 |
| NCAAB | 2021/01/17 22:00 | Santa Clara v San Diego | L | 69-63 |
| NCAAB | 2020/01/25 23:00 | Santa Clara v San Diego | L | 65-52 |
| NCAAB | 2020/01/04 22:00 | San Diego v Santa Clara | L | 63-80 |
| NCAAB | 2019/03/09 04:20 | San Diego v Santa Clara | W | 62-45 |
| NCAAB | 2019/01/04 03:00 | San Diego v Santa Clara | L | 56-68 |
| NCAAB | 2018/02/10 21:00 | San Diego v Santa Clara | L | 64-70 |
| NCAAB | 2018/01/26 03:00 | Santa Clara v San Diego | W | 58-66 |
| NCAAB | 2022/01/23 01:30 | San Diego v Pacific | W | 73-65 |
| NCAAB | 2022/01/21 03:00 | San Diego v BYU | L | 71-79 |
| NCAAB | 2022/01/15 08:27 | Loyola Marymount v San Diego | W | 65-70 |
| NCAAB | 2022/01/13 08:27 | Portland v San Diego | W | 63-68 |
| NCAAB | 2022/01/11 03:00 | San Diego v Pepperdine | W | 72-62 |
| NCAAB | 2022/01/09 00:00 | San Diego v San Francisco | L | 73-88 |
| NCAAB | 2021/12/23 03:00 | San Diego v UNLV | L | 57-80 |
| NCAAB | 2021/12/19 04:00 | San Diego v Northern Arizona | W | 69-59 |
| NCAAB | 2022/01/21 02:00 | Santa Clara v Saint Mary's CA | L | 65-73 |
| NCAAB | 2022/01/15 21:00 | Gonzaga v Santa Clara | L | 115-83 |
| NCAAB | 2022/01/13 03:00 | Santa Clara v Pacific | W | 84-70 |
| NCAAB | 2021/12/22 03:00 | Santa Clara v San Jose State | W | 79-57 |
| NCAAB | 2021/12/19 22:00 | Montana v Santa Clara | W | 64-79 |
| NCAAB | 2021/12/18 02:00 | Florida A&M v Santa Clara | W | 66-80 |
| NCAAB | 2021/12/15 02:00 | Santa Clara v Boise State | L | 60-72 |
| NCAAB | 2021/12/12 02:00 | Santa Clara v California | L | 60-72 |