Stadium: Leavey Center
Home Manager: Herb Sendek Away Manager: John Smith
| NCAAB | 2020/12/10 02:00 | Santa Clara v Cal Poly SLO | L | 76-69 |
| NCAAB | 2019/11/09 03:00 | Cal Poly SLO v Santa Clara | L | 63-77 |
| NCAAB | 2017/11/19 03:00 | Cal Poly SLO v Santa Clara | W | 63-59 |
| NCAAB | 2014/12/23 22:00 | Santa Clara v Cal Poly SLO | W | 58-69 |
| NCAAB | 2005/12/10 12:00 | Santa Clara v Cal Poly SLO | L | 73-58 |
| NCAAB | 2004/12/12 12:00 | Cal Poly SLO v Santa Clara | W | 98-89 |
| NCAAB | 2021/11/16 03:00 | Sacramento State v Cal Poly SLO | L | 58-57 |
| NCAAB | 2021/11/12 22:00 | North Dakota State v Cal Poly SLO | L | 60-57 |
| NCAAB | 2021/11/10 03:00 | Cal Poly SLO v Westcliff University | W | 86-53 |
| NCAAB | 2021/03/12 01:00 | Cal Poly SLO v UC Irvine | L | 51-58 |
| NCAAB | 2021/03/10 02:00 | Cal Poly SLO v CS Fullerton | W | 87-82 |
| NCAAB | 2021/03/07 01:00 | Cal Poly SLO v UC Santa Barbara | L | 54-70 |
| NCAAB | 2021/03/06 01:00 | Cal Poly SLO v UC Santa Barbara | L | 57-71 |
| NCAAB | 2021/02/27 22:00 | UC Davis v Cal Poly SLO | L | 68-66 |
| NCAAB | 2021/11/17 02:00 | Nevada v Santa Clara | W | 74-96 |
| NCAAB | 2021/11/13 04:00 | Stanford v Santa Clara | W | 72-88 |
| NCAAB | 2021/11/10 02:00 | CS Fullerton v Santa Clara | W | 77-84 |
| NCAAB | 2021/03/07 05:00 | Santa Clara v Pepperdine | L | 70-78 |
| NCAAB | 2021/03/06 05:00 | Santa Clara v Pacific | W | 81-76 |
| NCAAB | 2021/03/05 05:00 | Portland v Santa Clara | W | 86-95 |
| NCAAB | 2021/02/26 00:00 | Santa Clara v Gonzaga | L | 75-89 |
| NCAAB | 2021/02/20 23:00 | Pepperdine v Santa Clara | W | 82-86 |