Stadium: Jenny Craig Pavilion
Home Manager: Sam Scholl Away Manager: Herb Sendek
| NCAAB | 2022/01/25 02:00 | San Diego v Santa Clara | W | 74-78 |
| NCAAB | 2021/02/19 02:00 | San Diego v Santa Clara | L | 71-60 |
| NCAAB | 2021/01/17 22:00 | Santa Clara v San Diego | W | 69-63 |
| NCAAB | 2020/01/25 23:00 | Santa Clara v San Diego | W | 65-52 |
| NCAAB | 2020/01/04 22:00 | San Diego v Santa Clara | W | 63-80 |
| NCAAB | 2019/03/09 04:20 | San Diego v Santa Clara | L | 62-45 |
| NCAAB | 2019/01/04 03:00 | San Diego v Santa Clara | W | 56-68 |
| NCAAB | 2018/02/10 21:00 | San Diego v Santa Clara | W | 64-70 |
| NCAAB | 2022/02/04 02:00 | Loyola Marymount v Santa Clara | W | 60-79 |
| NCAAB | 2022/02/01 02:00 | Pacific v Santa Clara | W | 59-81 |
| NCAAB | 2022/01/30 00:00 | Santa Clara v San Francisco | L | 85-88 |
| NCAAB | 2022/01/28 04:00 | BYU v Santa Clara | W | 76-77 |
| NCAAB | 2022/01/25 02:00 | San Diego v Santa Clara | W | 74-78 |
| NCAAB | 2022/01/21 02:00 | Santa Clara v Saint Mary's CA | L | 65-73 |
| NCAAB | 2022/01/15 21:00 | Gonzaga v Santa Clara | L | 115-83 |
| NCAAB | 2022/01/13 03:00 | Santa Clara v Pacific | W | 84-70 |
| NCAAB | 2022/02/04 02:00 | Gonzaga v San Diego | L | 92-62 |
| NCAAB | 2022/01/30 00:00 | San Diego v Loyola Marymount | W | 69-65 |
| NCAAB | 2022/01/27 08:27 | Pepperdine v San Diego | W | 56-64 |
| NCAAB | 2022/01/25 02:00 | San Diego v Santa Clara | L | 74-78 |
| NCAAB | 2022/01/23 01:30 | San Diego v Pacific | W | 73-65 |
| NCAAB | 2022/01/21 03:00 | San Diego v BYU | L | 71-79 |
| NCAAB | 2022/01/15 08:27 | Loyola Marymount v San Diego | W | 65-70 |
| NCAAB | 2022/01/13 08:27 | Portland v San Diego | W | 63-68 |