Stadium: Cameron Indoor Stadium
Home Manager: Mike Krzyzewski Away Manager: Tony Madlock
| NCAAB | 2021/12/11 00:00 | High Point v South Carolina State | W | 66-67 |
| NCAAB | 2021/12/04 00:00 | South Carolina State v South Florida | W | 65-64 |
| NCAAB | 2021/11/28 19:00 | The Citadel v South Carolina State | L | 91-79 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | L | 82-78 |
| NCAAB | 2021/11/19 01:00 | South Carolina State v St. Andrew's | W | 67-53 |
| NCAAB | 2021/11/17 00:00 | South Carolina State v Georgia Bulldogs | L | 60-76 |
| NCAAB | 2021/11/14 00:30 | Lipscomb v South Carolina State | L | 93-81 |
| NCAAB | 2021/11/12 21:00 | Loyola Maryland v South Carolina State | L | 75-65 |
| NCAAB | 2021/12/01 02:30 | Duke v Ohio state | L | 66-71 |
| NCAAB | 2021/11/27 03:30 | Duke v Gonzaga | W | 84-81 |
| NCAAB | 2021/11/23 02:00 | The Citadel v Duke | W | 81-107 |
| NCAAB | 2021/11/20 01:00 | Lafayette v Duke | W | 55-88 |
| NCAAB | 2021/11/17 00:00 | Gardner Webb v Duke | W | 52-92 |
| NCAAB | 2021/11/14 01:00 | Campbell v Duke | W | 56-67 |
| NCAAB | 2021/11/13 00:00 | Army v Duke | W | 56-82 |
| NCAAB | 2021/11/10 02:30 | Kentucky v Duke | W | 71-79 |