Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Rob Ambrose
| NCAAF | 2019/10/26 19:30 | Towson v James Madison | L | 10-27 |
| NCAAF FCS | 2018/11/17 19:00 | James Madison v Towson | L | 38-17 |
| NCAAF | 2021/11/13 19:00 | Elon v Towson | L | 37-14 |
| NCAAF | 2021/11/06 18:00 | Towson v Richmond | L | 17-28 |
| NCAAF | 2021/10/30 18:00 | Albany v Towson | W | 24-38 |
| NCAAF | 2021/10/23 19:30 | Towson v William & Mary | L | 14-40 |
| NCAAF | 2021/10/16 20:00 | Rhode Island v Towson | W | 7-28 |
| NCAAF | 2021/10/09 20:00 | Stony Brook v Towson | W | 14-21 |
| NCAAF | 2021/09/25 19:30 | Towson v San Diego State | L | 21-48 |
| NCAAF | 2021/09/18 22:00 | North Dakota State v Towson | L | 35-7 |
| NCAAF | 2021/11/13 20:30 | James Madison v William & Mary | W | 32-22 |
| NCAAF | 2021/11/06 19:30 | Campbell v James Madison | W | 14-51 |
| NCAAF | 2021/10/30 18:00 | Elon v James Madison | W | 21-45 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |
| NCAAF | 2021/10/16 18:00 | James Madison v Richmond | W | 19-3 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | L | 28-27 |
| NCAAF | 2021/10/02 19:30 | James Madison v New Hampshire | W | 23-21 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | W | 37-24 |