Stadium: Elliott T. Bowers Stadium Round: 1
Home Manager: K.C. Keeler Away Manager: Walt Wells
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | L | 17-31 |
| NCAAF | 2021/10/30 18:00 | Lamar v Eastern Kentucky | W | 10-42 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | W | 38-35 |
| NCAAF | 2021/10/09 22:00 | Abilene Christian v Eastern Kentucky | W | 15-30 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | W | 3-20 |
| NCAAF | 2021/09/25 19:00 | Austin Peay v Eastern Kentucky | W | 27-35 |
| NCAAF | 2021/09/18 23:00 | Indiana State v Eastern Kentucky | L | 23-21 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | L | 3-30 |
| NCAAF | 2021/11/06 17:00 | Utah Tech v Sam Houston State | W | 10-59 |
| NCAAF | 2021/10/30 23:00 | Sam Houston State v Tarleton State | W | 45-27 |
| NCAAF | 2021/10/23 19:00 | Jacksonville State v Sam Houston State | W | 7-42 |
| NCAAF | 2021/10/09 19:00 | Lamar v Sam Houston State | W | 7-41 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | W | 21-20 |
| NCAAF | 2021/09/25 21:00 | Sam Houston State v Central Arkansas | W | 45-35 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | W | 14-52 |
| NCAAF | 2021/09/03 01:00 | Sam Houston State v Northern Arizona | W | 42-16 |