Stadium: Elliott T. Bowers Stadium Round: 1
Home Manager: K.C. Keeler Away Manager: John Grass
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | W | 24-28 |
| NCAAF | 2021/10/02 19:00 | Jacksonville State v Kennesaw State | L | 6-31 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | L | 34-31 |
| NCAAF | 2021/09/18 23:00 | North Alabama v Jacksonville State | W | 24-27 |
| NCAAF | 2021/09/12 00:00 | Jacksonville State v Florida State | W | 20-17 |
| NCAAF | 2021/09/01 23:30 | UAB v Jacksonville State | L | 31-0 |
| NCAAF | 2021/05/02 19:00 | Delaware v Jacksonville State | L | 20-14 |
| NCAAF | 2021/04/24 18:00 | Davidson Wildcats v Jacksonville State | W | 14-49 |
| NCAAF | 2021/10/09 19:00 | Lamar v Sam Houston State | W | 7-41 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | W | 21-20 |
| NCAAF | 2021/09/25 21:00 | Sam Houston State v Central Arkansas | W | 45-35 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | W | 14-52 |
| NCAAF | 2021/09/03 01:00 | Sam Houston State v Northern Arizona | W | 42-16 |
| NCAAF | 2021/05/16 18:00 | Sam Houston State v South Dakota State | W | 23-21 |
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | W | 35-38 |
| NCAAF | 2021/05/02 19:00 | North Dakota State v Sam Houston State | W | 20-24 |