Stadium: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: Blane Morgan
| NCAAF | 2021/10/23 23:00 | Central Arkansas v Lamar | L | 49-38 |
| NCAAF | 2021/10/16 20:00 | Lamar v Abilene Christian | L | 17-24 |
| NCAAF | 2021/10/09 19:00 | Lamar v Sam Houston State | L | 7-41 |
| NCAAF | 2021/09/25 23:00 | Abilene Christian v Lamar | L | 56-0 |
| NCAAF | 2021/09/18 20:00 | Lamar v Northern Colorado | W | 17-10 |
| NCAAF | 2021/09/11 22:00 | Lamar v Texas-San Antonio | L | 0-54 |
| NCAAF | 2021/09/03 00:00 | Lamar v North American Stallions | W | 47-3 |
| NCAAF | 2021/04/03 23:00 | Lamar v SE Louisiana | L | 12-42 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | W | 38-35 |
| NCAAF | 2021/10/09 22:00 | Abilene Christian v Eastern Kentucky | W | 15-30 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | W | 3-20 |
| NCAAF | 2021/09/25 19:00 | Austin Peay v Eastern Kentucky | W | 27-35 |
| NCAAF | 2021/09/18 23:00 | Indiana State v Eastern Kentucky | L | 23-21 |
| NCAAF | 2021/09/11 23:00 | Eastern Kentucky v Louisville | L | 3-30 |
| NCAAF | 2021/09/04 22:00 | Eastern Kentucky v Western Carolina | W | 31-28 |
| NCAAF | 2020/11/21 20:00 | Western Carolina v Eastern Kentucky | W | 17-49 |