Stadium: Joe Walton Stadium Round: 1
Home Manager: Bernard Clark Away Manager: Autry Denson
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | L | 28-31 |
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | L | 41-14 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | W | 38-21 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | W | 7-20 |
| NCAAF | 2021/04/10 16:00 | Robert Morris v Charleston Southern | W | 14-27 |
| NCAAF | 2021/03/27 17:00 | Charleston Southern v Monmouth | L | 17-35 |
| NCAAF | 2021/03/13 18:00 | Charleston Southern v Kennesaw State | L | 19-24 |
| NCAAF | 2019/11/23 20:30 | Campbell v Charleston Southern | W | 31-41 |
| NCAAF | 2021/10/02 17:00 | Robert Morris v North Carolina A&T | L | 14-41 |
| NCAAF | 2021/09/25 16:00 | Howard v Robert Morris | W | 16-22 |
| NCAAF | 2021/09/11 19:00 | Robert Morris v Central Michigan | L | 0-45 |
| NCAAF | 2021/04/10 16:00 | Robert Morris v Charleston Southern | L | 14-27 |
| NCAAF | 2021/04/03 17:00 | Robert Morris v Kennesaw State | L | 0-35 |
| NCAAF | 2021/02/27 17:00 | Robert Morris v James Madison | L | 16-36 |
| NCAAF | 2019/11/23 17:00 | Sacred Heart v Robert Morris | W | 14-16 |
| NCAAF | 2019/11/16 17:00 | Robert Morris v Central Connecticut | L | 28-49 |