[13] Southampton 0-0 West Ham [2] 2021-09-11 14:00
Stadium: St. Mary's Stadium Round: 4
Referee: David Coote Home Manager: Ralph Hasenhuttl Away Manager: David Moyes
Head to Head
| England - Premier League | 2021/05/23 15:00 | West Ham v Southampton | L | 3-0 |
| England - Premier League | 2020/12/29 18:00 | Southampton v West Ham | D | 0-0 |
| England - Premier League | 2020/02/29 15:00 | West Ham v Southampton | L | 3-1 |
| England - Premier League | 2019/12/14 17:30 | Southampton v West Ham | L | 0-1 |
| England - Premier League | 2019/05/04 14:00 | West Ham v Southampton | L | 3-0 |
| England - Premier League | 2018/12/27 19:45 | Southampton v West Ham | L | 1-2 |
| England - Premier League | 2018/03/31 14:00 | West Ham v Southampton | L | 3-0 |
| England - Premier League | 2017/08/19 14:00 | Southampton v West Ham | W | 3-2 |
Home History
| England - Premier League | 2021/08/28 14:00 | Newcastle v Southampton | D | 2-2 |
| England - EFL Cup | 2021/08/25 18:45 | Newport County v Southampton | W | 0-8 |
| England - Premier League | 2021/08/22 13:00 | Southampton v Man Utd | D | 1-1 |
| England - Premier League | 2021/08/14 14:00 | Everton v Southampton | L | 3-1 |
| Europa - Vennskapskamper | 2021/08/07 14:00 | Southampton v Athletic Bilbao | L | 1-3 |
| Europa - Vennskapskamper | 2021/08/04 18:00 | Southampton v Levante | W | 1-0 |
| Vennskapskamper - Eliteklubber | 2021/07/31 14:00 | Swansea v Southampton | W | 1-3 |
| Europa - Vennskapskamper | 2021/07/27 18:00 | Cardiff v Southampton | W | 0-4 |
Away History
| England - Premier League | 2021/08/28 14:00 | West Ham v Crystal Palace | D | 2-2 |
| England - Premier League | 2021/08/23 19:00 | West Ham v Leicester | W | 4-1 |
| England - Premier League | 2021/08/15 13:00 | Newcastle v West Ham | W | 2-4 |
| Europa - Vennskapskamper | 2021/08/07 14:00 | West Ham v Atalanta | W | 2-0 |
| Europa - Vennskapskamper | 2021/07/31 14:00 | Brentford v West Ham | W | 0-1 |
| Europa - Vennskapskamper | 2021/07/24 14:00 | Celtic v West Ham | W | 2-6 |
| Europa - Vennskapskamper | 2021/07/21 18:00 | Reading v West Ham | W | 0-3 |
| Europa - Vennskapskamper | 2021/07/13 18:00 | Leyton Orient v West Ham | D | 0-0 |