[35] Reilly Opelka 4-6,2-6,4-6 Daniil Medvedev [2] 2021-06-04 13:40
Stadium: Court Suzanne Lenglen Round: 25 Ground: Clay
Head to Head
| ATP St Petersburg | 2020/10/15 14:00 | Daniil Medvedev v Reilly Opelka | 6-2,5-7,4-6 |
| ATP Miami | 2019/03/25 20:05 | Daniil Medvedev v Reilly Opelka | 7-6,6-7,7-6 |
| ATP Washington | 2017/08/01 00:40 | Daniil Medvedev v Reilly Opelka | 6-7,6-3,7-6 |
Home History
| French Open | 2021/06/02 13:45 | Reilly Opelka v Jaume Munar | 6-3,6-2,3-6,7-5 |
| French Open | 2021/05/31 12:15 | Reilly Opelka v Andrej Martin | 6-3,6-2,6-4 |
| ATP Genéve | 2021/05/18 11:10 | Pablo Cuevas v Reilly Opelka | 7-6,6-2 |
| ATP Roma | 2021/05/15 13:50 | Reilly Opelka v Rafael Nadal | 4-6,4-6 |
| ATP Roma | 2021/05/14 08:00 | Federico Delbonis v Reilly Opelka | 5-7,6-7 |
| ATP Roma | 2021/05/13 08:00 | Reilly Opelka v Aslan Karatsev | 7-6,6-4 |
| ATP Roma | 2021/05/11 11:10 | Lorenzo Musetti v Reilly Opelka | 4-6,4-6 |
| ATP Roma | 2021/05/09 13:30 | Richard Gasquet v Reilly Opelka | 1-6,5-7 |
Away History
| French Open | 2021/06/02 19:00 | Tommy Paul v Daniil Medvedev | 6-3,1-6,4-6,3-6 |
| French Open | 2021/05/31 11:45 | Alexander Bublik v Daniil Medvedev | 3-6,3-6,5-7 |
| ATP Roma | 2021/05/12 12:05 | Aslan Karatsev v Daniil Medvedev | 6-2,6-4 |
| ATP Madrid | 2021/05/06 10:30 | Cristian Garin v Daniil Medvedev | 6-4,6-7,6-1 |
| ATP Madrid | 2021/05/05 09:00 | Alejandro Davidovich Fokina v Daniil Medvedev | 6-4,4-6,2-6 |
| ATP Miami | 2021/04/01 02:10 | Daniil Medvedev v Roberto Bautista-Agut | 4-6,2-6 |
| ATP Miami | 2021/03/30 20:20 | Daniil Medvedev v Frances Tiafoe | 6-4,6-3 |
| ATP Miami | 2021/03/28 19:20 | Daniil Medvedev v Alexei Popyrin | 7-6,6-7,6-4 |