Stadium: John O'Quinn Field at TDECU Stadium Round: 1
Home Manager: Dana Holgorsen Away Manager: Eric Dooley
| NCAAF | 2019/08/31 22:30 | Prairie View v Texas Southern Tigers | W | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern Tigers v Prairie View | W | 14-60 |
| NCAAF FCS | 2018/11/17 19:00 | Alabama State v Prairie View | W | 13-66 |
| NCAAF FCS | 2018/11/03 19:00 | Prairie View v Jackson State | L | 28-34 |
| NCAAF | 2018/10/27 19:00 | Prairie View v Alcorn State | L | 13-27 |
| NCAAF | 2018/10/13 22:00 | Southern v Prairie View | L | 38-0 |
| NCAAF | 2018/09/29 21:00 | Prairie View v Grambling State | W | 22-16 |
| NCAAF | 2018/09/22 23:00 | Prairie View v Arkansas Pine Bluff | W | 62-13 |
| NCAAF | 2019/09/01 23:30 | Houston v Oklahoma | L | 31-49 |
| NCAAF | 2018/12/22 20:30 | Houston v Army | L | 14-70 |
| NCAAF | 2018/11/23 17:00 | Houston v Memphis | L | 31-52 |
| NCAAF | 2018/11/16 01:00 | Tulane v Houston | W | 17-48 |
| NCAAF | 2018/11/11 00:00 | Temple v Houston | L | 59-49 |
| NCAAF | 2018/11/03 23:00 | Houston v SMU | L | 31-45 |
| NCAAF | 2018/10/27 19:30 | South Florida v Houston | W | 36-57 |
| NCAAF | 2018/10/20 19:30 | Houston v Navy | W | 49-36 |